Search results for "bioactive lipid"

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Lipid profiling following intake of the Omega 3 fatty acid DHA identifies the peroxidized metabolites F-4-Neuroprostanes as the best predictors of at…

2014

International audience; The anti-atherogenic effects of omega 3 fatty acids, namely eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) are well recognized but the impact of dietary intake on bioactive lipid mediat or profiles remains unclear. Such a profiling effort may offer novel targets for future studies into the mechanism of action of omega 3 fatty acids. The present study aimed to determine the impact of DHA supplementation on the profiles of polyunsaturated fatty acids (PUFA) oxygenated metabolites and to investigate their contribution to therosclerosis prevention. A special emphasis was given to the non-enzymatic metabolites knowing the high susceptibility of DHA to free radical…

MouseBlood PressureCardiovascularBiochemistryMice0302 clinical medicineTandem Mass SpectrometryAetiologylcsh:Sciencechemistry.chemical_classificationLiquid0303 health sciences[CHIM.ORGA]Chemical Sciences/Organic chemistryFatty Acidsanti-atherogenic;omega 3 fatty acids;epa;dha;bioactive lipid;atherosclerosis;pufas;effects;molecularLipids3. Good healthFatty Acids UnsaturatedMedicinemedicine.medical_specialtyanti-atherogenicKnockoutAortic DiseasesMédecine humaine et pathologieGas Chromatography-Mass SpectrometryLDLDose-Response RelationshipLipid Mediators03 medical and health sciencesomega 3 fatty acids[ CHIM.ORGA ] Chemical Sciences/Organic chemistryacide gras n 3Complementary and Integrative HealtheffectsBiologybioactive lipidDose-Response Relationship DrugPreventionlcsh:RathéroscléroseEPALipid MetabolismPrevention of disease and conditionsmedicine.diseaseEndocrinologychemistryNeuroprostaneslcsh:QHuman health and pathologyBiomarkersand promotion of well-beinglcsh:Medicine030204 cardiovascular system & hematologymedicine.disease_causeOral and gastrointestinalHeart RateReceptorsBlood plasmaCluster Analysis2.1 Biological and endogenous factorsMice KnockoutUnsaturatedChromatographyMultidisciplinaryFatty liverAnimal ModelsDHALiverBiochemistryDocosahexaenoic acidlipids (amino acids peptides and proteins)DrugResearch ArticlePolyunsaturated fatty acidDocosahexaenoic AcidsClinical Research DesignGeneral Science & TechnologyBiologyModel OrganismsInternal medicinemedicineAnimalsNeuroprostanesAnimal Models of Diseasemolecular3.3 Nutrition and chemopreventionOmega 3 fatty acidNutrition030304 developmental biologyAnalysis of Varianceacide docosahexaénoiqueLipid metabolismAtherosclerosis[SDV.AEN] Life Sciences [q-bio]/Food and NutritionReceptors LDLPUFAs[SDV.AEN]Life Sciences [q-bio]/Food and NutritionOxidative stressChromatography Liquid
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